Treatment of erectile dysfunction is much easier now, thanks to a class of drugs called phosphodiesterase-5 (PDE-5) inhibitors. The medications — sildenafil (Viagra), vardenafil (Levitra) and tadalafil (Cialis) — all improve erectile function in the same basic way, but they differ in how quickly they take effect and how long their effects last.
Viagra, Levitra and Cialis prevent the breakdown of nitric oxide, a chemical messenger that promotes relaxation and opening of the blood vessels that supply erectile tissue in the penis. Under the influence of nitric oxide, these vessels expand and stay dilated. Increased blood flow makes erectile tissue swell and compress the veins that carry blood out of the penis, resulting in a full erection.
Many clinical trials have shown that PDE-5 inhibitors improve erectile function regardless of the underlying cause or causes. Viagra, Levitra and Cialis increase the number and quality of erections and sexual experiences in men with erectile dysfunction due to arteriosclerosis, diabetes, spinal cord injury, depression or the aftereffects of prostate cancer surgery.
The drugs have slightly different chemical compositions that affect how quickly they work and wear off. Other distinctions — for example, which drug may be best for men of different ages or with different medical conditions — aren't known. No study has directly compared these three medications.
Several factors may affect your choice of medication, including how well your body responds to one drug over another and how long you want the effects of each dose to last. Talk to your doctor about your options and personal preferences to help decide which one of these medications might work for you.
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